Warfarin (PIM 563)by NR GN4550000The average half-life of warfarin was found to be 36 hours in healthy volunteers; a range of 20 to 80 hours has been reported in volunteers (Hackett et al., 1985; OThe half-life of warfarin after a massive overdose of 2000 mg in an adult was 21.7 hours (Hackett et al., 1985). The half- life in another patient who overdosed on an unknown amount was 53 hours (Renowden et al., 1985).
Coumadin Clinical PharmacologyCoumadin Clinical Pharmacology.The terminal half-life of warfarin after a single dose is approximately one week; however, the effective half-life ranges from 20 to 60 hours, with a mean of about 40 hours. The clearance of R-warfarin is generally half that of S-warfarin, thus as the volumes of distribution are similar, the
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WarfarinFactor II (72 hour half life); Factor VII (8 hour half life); Factor IX (24 hour half life); Factor X (39 hour half life). Anticoagulant Activity. Protein C (14 hour half life); Protein S (42 hour half life). Coumadin has an initial paradoxical procoagulant effectEnglish, Boots Brand of Warfarin Sodium, Bristol-Myers Squibb Brand of Warfarin Sodium, Coumadin, Goldshield Brand of Warfarin Sodium, Marevan
PTINR.com - Warfarin Half-LifeWarfarin half-life allows for some flexibility is dosing and provides a safety margin.Whether you are a doctor, nurse, patient, son or daughter or grand child of a patient on CoumadinÒ it is essential that the half-life of the drug CoumadinÒ in clearly understood. The “half-life” is the time
Coumadin (Warfarin Sodium) Drug Information: Uses, Side EffectsTherefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to COUMADIN (Warfarin Sodium) overdosage.The terminal half-life of warfarin after a single dose is approximately 1 week; however, the effective half-life ranges from 20 to 60 hours, with a mean of aboutThe half-life of R-warfarin ranges from 37 to 89 hours, while that of S-warfarin ranges from 21 to 43 hours. Studies
Warfarin - Wikipedia, the free encyclopediaCoumarin, not to be confused with Coumadin, a brand name for warfarin, itself has no effect on clotting, or upon the action of warfarin. WarfarinWarfarin has a long half-life and need only be given once a day. Heparin can also cause a prothrombotic condition, heparin-induced thrombocytopenia (an antibodyWarfarin's long half life means that it remains effective for several days after it was stopped. Furthermore, if given initially without additional anticoagulantHistory - Therapeutic uses - Contraindications - Adverse effects